Resolution of paraneoplastic bile duct paucity following successful treatment of Hodgkin's disease

Hepatology. 1997 Jul;26(1):5-8. doi: 10.1002/hep.510260101.

Abstract

We report the case of a 21-year-old woman who developed severe adult onset ductopenia in association with Hodgkin's lymphoma. Chemotherapy resulted in a remission of her Hodgkin's disease (HD) and significant improvement in liver function with resolution of the hepatic and biliary duct histological abnormalities, a therapeutic success not previously described in the literature.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Alkaline Phosphatase / blood
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
  • Bile Duct Diseases / complications*
  • Bile Duct Diseases / pathology
  • Bilirubin / blood
  • Biopsy
  • Female
  • Hodgkin Disease / complications
  • Hodgkin Disease / drug therapy*
  • Humans
  • Mechlorethamine / administration & dosage
  • Procarbazine / administration & dosage
  • Vincristine / administration & dosage
  • gamma-Glutamyltransferase / blood

Substances

  • Procarbazine
  • Mechlorethamine
  • Vincristine
  • gamma-Glutamyltransferase
  • Alkaline Phosphatase
  • Bilirubin