Studies on chemical modification of monensin. VI. Preparation of C-7 modified monensins via protected 7-oxomonensin and evaluation of their ion transport activity

A Nagatsu; Y Tabunoki; S Nagai; T Ueda; J Sakakibara; H Hidaka

doi:10.1248/cpb.45.966

Studies on chemical modification of monensin. VI. Preparation of C-7 modified monensins via protected 7-oxomonensin and evaluation of their ion transport activity

Chem Pharm Bull (Tokyo). 1997 Jun;45(6):966-70. doi: 10.1248/cpb.45.966.

Authors

A Nagatsu¹, Y Tabunoki, S Nagai, T Ueda, J Sakakibara, H Hidaka

Affiliation

¹ Faculty of Pharmaceutical Sciences, Nagoya City University, Japan.

PMID: 9214703
DOI: 10.1248/cpb.45.966

Abstract

7-Carboxymethylmonensin (3), 7-aminomonensin (4), and 7-oxomonensin (5) were synthesized via protected 7-oxomonensin (2), which is expected to be a useful intermediate for the preparation of various monensin derivatives. intermediate for the preparation of various monensin derivatives. Compounds 3-5 exhibited smaller ion transport activity than monensin (1).

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Calcium / metabolism
Erythrocyte Membrane / drug effects
Erythrocyte Membrane / metabolism
Humans
Ion Transport / drug effects*
Ionophores / chemistry*
Ionophores / pharmacology
Magnetic Resonance Spectroscopy
Models, Chemical
Monensin / analogs & derivatives*
Monensin / chemistry
Monensin / metabolism
Monensin / pharmacology
Sodium / metabolism

Substances

7-oxomonensin
Ionophores
Monensin
Sodium
Calcium