Abstract
Two related 1H-2,3,3a,8b-tetrahydrocyclopenta[b]benzofurans, aglafolin (1a) and rocaglamide (2), isolated from the stems of Aglaia elliptifolia, showed significant cytotoxicity in six cancer cell lines. Aglafolin (1a) was also found to completely block platelet aggregation caused by arachidonic acid and platelet-activating factor at 100 microM and 2 ng/mL, respectively.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Antineoplastic Agents, Phytogenic / isolation & purification*
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Antineoplastic Agents, Phytogenic / pharmacology
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Benzofurans / isolation & purification*
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Benzofurans / pharmacology
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Drug Screening Assays, Antitumor
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Humans
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In Vitro Techniques
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Magnetic Resonance Spectroscopy
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Mass Spectrometry
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Mice
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Plant Extracts / chemistry
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Platelet Aggregation / drug effects
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Platelet Aggregation Inhibitors / isolation & purification*
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Platelet Aggregation Inhibitors / pharmacology
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Rabbits
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Spectrophotometry, Infrared
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Spectrophotometry, Ultraviolet
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Tumor Cells, Cultured
Substances
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Antineoplastic Agents, Phytogenic
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Benzofurans
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Plant Extracts
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Platelet Aggregation Inhibitors
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aglafoline
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rocaglamide