Abstract
The Junin virus strain Candid #1 was developed as a live attenuated vaccine for Argentine haemorrhagic fever. In this paper we report the nucleotide sequences of S RNA of Candid #1 and its more virulent ancestors XJ#44 and XJ (prototype). Their relationship to Junin virus wild-type MC2 strain and other closely and distantly related arenaviruses was also examined. Comparisons of the nucleotide and amino acid sequences of N and GPC genes from Candid #1 and its progenitor strains revealed some changes that are unique to the vaccine strain. These changes could be provisionally associated with the attenuated phenotype.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Amino Acid Sequence
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Animals
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Cell Line
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Cricetinae
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Humans
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Junin virus / genetics*
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Molecular Sequence Data
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Nucleocapsid / genetics
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RNA, Viral
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Sequence Homology, Amino Acid
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Vaccines, Attenuated / genetics
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Viral Envelope Proteins / genetics
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Viral Vaccines / genetics*
Substances
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RNA, Viral
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Vaccines, Attenuated
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Viral Envelope Proteins
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Viral Vaccines
Associated data
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GENBANK/D10072
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GENBANK/J04324
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GENBANK/K02734
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GENBANK/M20304
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GENBANK/M20869
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GENBANK/M22138
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GENBANK/M33879
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GENBANK/M65834
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GENBANK/U34248
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GENBANK/U70799
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GENBANK/U70800
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GENBANK/U70801
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GENBANK/U70802
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GENBANK/U70803
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GENBANK/U70804
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GENBANK/X52400
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GENBANK/X62616