Abstract
We have recently shown that French small ruminant lentiviruses (SRLV) from sheep are more similar to Caprine Arthritis Encephalitis Virus (CAEV) than to visna maedi virus (VMV) in a conserved region of the pol gene. To extend these results, we have examined sequences from a variable region of the env gene in French SRLV. We found that they were nearly equally distant from both CAEV and VMV strains, suggesting a considerable divergence since the initial introduction of the virus. Analysis of separate clones from individual animals showed that some carry a population of variant viruses. The study of further pol gene sequences from both goats and sheep suggests that viral variants show little or no host species specificity. A phylogenetic tree of pol gene sequences confirmed the presence of a novel genotype of SRLV in France.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Animals
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Base Sequence
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DNA, Viral
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Genes, env
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Genes, pol
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Genetic Heterogeneity
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Genome, Viral
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Genotype
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Goats
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Lentiviruses, Ovine-Caprine / classification
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Lentiviruses, Ovine-Caprine / genetics*
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Molecular Sequence Data
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Phylogeny
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Polymerase Chain Reaction
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Ruminants / virology
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Sequence Homology, Amino Acid
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Sheep
Associated data
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GENBANK/U35674
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GENBANK/U35675
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GENBANK/U35676
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GENBANK/U35677
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GENBANK/U35678
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GENBANK/U35679
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GENBANK/U35680
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GENBANK/U35681
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GENBANK/U35795
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GENBANK/U35796
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GENBANK/U35797
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GENBANK/U35798
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GENBANK/U35799
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GENBANK/U35800
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GENBANK/U35801
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GENBANK/U35802
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GENBANK/U35803
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GENBANK/U35804
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GENBANK/U35805
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GENBANK/U35806
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GENBANK/U35807
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GENBANK/U35808
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GENBANK/U35809
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GENBANK/U35810
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GENBANK/U35811
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GENBANK/U35812
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GENBANK/U35813
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GENBANK/U35814
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GENBANK/U35857
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GENBANK/U35858