Identification of wallaby milk whey proteins separated by two-dimensional electrophoresis, using amino acid analysis and sequence tagging

Electrophoresis. 1997 Jun;18(7):1073-8. doi: 10.1002/elps.1150180708.

Abstract

Micropreparative two-dimensional polyacrylamide gel electrophoresis has been used to separate milk whey proteins from the Tammar wallaby (Macropus eugenii). We have used a combination of amino acid analysis and N-terminal sequence tagging as a rapid and sensitive method to identify the major whey proteins. Using these techniques, we confidently identified alpha-lactalbumin and late lactation protein. While these are the only two M. eugenii whey proteins with a corresponding SWISS-PROT entry, we demonstrate that by using amino acid analysis and matching across species boundaries, we can identify previously unsequenced conserved wallaby whey proteins including beta-lactoglobulin and serum albumin.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Amino Acids / analysis*
  • Animals
  • Electrophoresis, Gel, Two-Dimensional / methods*
  • Humans
  • Lactalbumin / analysis
  • Macropodidae
  • Milk Proteins / analysis*
  • Milk Proteins / chemistry
  • Molecular Sequence Data
  • Sequence Analysis / methods
  • Whey Proteins

Substances

  • Amino Acids
  • Milk Proteins
  • Whey Proteins
  • Lactalbumin