Regulation of B-cell commitment to plasma cells or to memory B cells

Semin Immunol. 1997 Aug;9(4):235-40. doi: 10.1006/smim.1997.0080.

Abstract

During humoral immune responses, B-lymphocyte activation is followed by differentiation along either the plasma cell pathway or the memory B-cell pathway. Recent studies suggest that CD40-CD40 ligand, OX-OX40 ligand, a group of cytokines and intracellular transcriptional factors may all contribute to B-lymphocyte differentiation control.

Publication types

  • Review

MeSH terms

  • Animals
  • B-Lymphocytes / cytology*
  • B-Lymphocytes / immunology*
  • B-Lymphocytes / metabolism
  • CD40 Antigens / metabolism
  • CD40 Ligand
  • Cell Differentiation
  • Humans
  • Immunologic Memory*
  • Interleukins / metabolism
  • Lymphocyte Activation
  • Membrane Glycoproteins / metabolism
  • OX40 Ligand
  • Plasma Cells / cytology*
  • Plasma Cells / immunology*
  • Plasma Cells / metabolism
  • Receptors, OX40
  • Receptors, Tumor Necrosis Factor / metabolism
  • Transcription Factors / metabolism
  • Tumor Necrosis Factor Receptor Superfamily, Member 7 / metabolism

Substances

  • CD40 Antigens
  • Interleukins
  • Membrane Glycoproteins
  • OX40 Ligand
  • Receptors, OX40
  • Receptors, Tumor Necrosis Factor
  • TNFRSF4 protein, human
  • TNFSF4 protein, human
  • Transcription Factors
  • Tumor Necrosis Factor Receptor Superfamily, Member 7
  • CD40 Ligand