Abstract
Three patients with recurrent vascular catheter-related bacteremia were successfully treated by allowing a solution of minocycline and ethylenediaminetetraacetate (EDTA) to dwell in the lumen of the indwelling catheter or by coating polyurethane catheters with minocycline/EDTA and flushing the lumen daily with the same solution. In vitro and in vivo experiments showed that minocycline/EDTA may have broad-spectrum antimicrobial activity, may have optimal anticoagulant activity, and may be highly efficacious in preventing catheter colonization.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Anti-Bacterial Agents / therapeutic use*
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Anticoagulants / therapeutic use
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Bacteremia / etiology
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Bacteremia / prevention & control*
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Catheterization, Central Venous / adverse effects*
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Drug Therapy, Combination
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Edetic Acid / therapeutic use*
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Enterobacter / isolation & purification
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Enterobacteriaceae Infections / etiology
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Enterobacteriaceae Infections / prevention & control*
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Fatal Outcome
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Female
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Humans
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Male
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Middle Aged
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Minocycline / therapeutic use*
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Recurrence
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Staphylococcal Infections / etiology
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Staphylococcal Infections / prevention & control*
Substances
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Anti-Bacterial Agents
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Anticoagulants
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Edetic Acid
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Minocycline