This is a case report of a female patient who tried another regimen after EMA-CO regimen failed. A 30-year-old female, gravida 4, para 2, abortus 2, blood grouping O (grouping B of her husband), was a victim of choriocarcinoma of the uterus and was resistant to multiple combination regimens of chemotherapy (EMA-CO, EMA-PE, BEP). She was finally cured by the VIP regimen of chemotherapy. The VIP regimen may be considered as an effective protocol to cure refractory choriocarcinoma.