Abstract
A new culture medium has been developed to evaluate the activity of trimethoprim and sulfamethoxazole against Borrelia burgdorferi in vitro. In this specially modified Barbour-Stoenner-Kelly medium, in which antagonizing substances were reduced to a minimum, trimethoprim was more active against Borrelia burgdorferi than against a sensitive strain of Escherichia coli, but sulfamethoxazole was not active against Borrelia burgdorferi.
MeSH terms
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Anti-Bacterial Agents*
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Anti-Infective Agents, Urinary / pharmacology*
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Borrelia burgdorferi Group / drug effects*
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Borrelia burgdorferi Group / physiology
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Colony Count, Microbial
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Culture Media / chemistry*
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Drug Evaluation, Preclinical
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Drug Therapy, Combination / pharmacology*
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Escherichia coli / drug effects*
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Escherichia coli / physiology
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Microbial Sensitivity Tests
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Sulfamethoxazole / pharmacology*
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Trimethoprim / pharmacology*
Substances
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Anti-Bacterial Agents
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Anti-Infective Agents, Urinary
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Culture Media
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Trimethoprim
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Sulfamethoxazole