Kawaguchipeptin B, an antibacterial cyclic undecapeptide from the cyanobacterium Microcystis aeruginosa

K Ishida; H Matsuda; M Murakami; K Yamaguchi

doi:10.1021/np970146k

Kawaguchipeptin B, an antibacterial cyclic undecapeptide from the cyanobacterium Microcystis aeruginosa

J Nat Prod. 1997 Jul;60(7):724-6. doi: 10.1021/np970146k.

Authors

K Ishida¹, H Matsuda, M Murakami, K Yamaguchi

Affiliation

¹ Laboratory of Marine Biochemistry, Graduate School of Agricultural Life Sciences, University of Tokyo, Japan.

PMID: 9249979
DOI: 10.1021/np970146k

Abstract

Kawaguchipeptin B, an antibacterial cyclic undecapeptide, was isolated from the cultured cyanobacterium Microcystis aeruginosa (NIES-88). Its structure was elucidated as 1 on the basis of 2D NMR data and chemical degradation. Kawaguchipeptin B (1) inhibited the growth of the Gram-positive bacterium Staphylococcus aureus at a concentration of 1 microgram/mL (MIC).

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-Bacterial Agents / chemistry
Anti-Bacterial Agents / pharmacology*
Chromatography, Gas
Chromatography, High Pressure Liquid
Magnetic Resonance Spectroscopy
Microcystis / chemistry*
Peptides*
Peptides, Cyclic
Protein Conformation
Staphylococcus aureus / drug effects*

Substances

Anti-Bacterial Agents
Peptides
Peptides, Cyclic
kawaguchipeptin B