Abstract
We studied modifications in [3H]MK801-binding sites in the rat brain after chronic clozapine. We found a 20-30% reduction of [3H]MK801-binding sites in the anterior cingulate, frontoparietal motor and frontoparietal somatosensory cortices on the left side but none on the right. We also demonstrated a 20% bilateral increase of N-methyl-D-aspartate (NMDA) receptors in the dentate gyrus of the hippocampus. No changes were found in the prefrontal cortex, caudate-putamen, nucleus accumbens, hippocampus or olfactory tubercle.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antipsychotic Agents / pharmacology*
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Autoradiography
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Binding Sites / physiology
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Brain Chemistry / physiology
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Cerebral Cortex / chemistry*
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Cerebral Cortex / metabolism
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Clozapine / pharmacology*
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Dizocilpine Maleate / metabolism
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Dizocilpine Maleate / pharmacology*
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Excitatory Amino Acid Antagonists / metabolism
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Excitatory Amino Acid Antagonists / pharmacology*
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Male
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Rats
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Rats, Sprague-Dawley
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Receptors, N-Methyl-D-Aspartate / antagonists & inhibitors
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Time Factors
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Tritium
Substances
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Antipsychotic Agents
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Excitatory Amino Acid Antagonists
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Receptors, N-Methyl-D-Aspartate
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Tritium
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Dizocilpine Maleate
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Clozapine