Abstract
The influence of bovine lactoferrin (bLF) on colon carcinogenesis was investigated in male F344 rats treated with azoxymethane (AOM). Following three weekly injections of AOM, the animals received 2 or 0.2% bLF for 36 weeks. No effects indicative of toxicity were noted, but significant reduction in both the incidence and number of adenocarcinomas of the large intestine was observed with both doses. Thus, the incidences of adenocarcinomas in the groups receiving 2% and 0.2% bLF were 15% and 25%, respectively, in contrast to the 57.5% control value (P < 0.01 and P < 0.05, respectively). The results indicate that bLF might find application for chemoprevention of colon cancer.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adenocarcinoma / chemically induced
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Adenocarcinoma / pathology
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Adenocarcinoma / prevention & control*
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Adenoma / chemically induced
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Adenoma / pathology
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Adenoma / prevention & control
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Animals
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Anticarcinogenic Agents / pharmacology*
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Azoxymethane / antagonists & inhibitors
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Azoxymethane / toxicity*
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Carcinoma / chemically induced
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Carcinoma / pathology
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Carcinoma / prevention & control
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Cattle
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Colonic Neoplasms / chemically induced
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Colonic Neoplasms / pathology
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Colonic Neoplasms / prevention & control*
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Incidence
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Intestinal Neoplasms / chemically induced
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Intestinal Neoplasms / pathology
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Intestinal Neoplasms / prevention & control*
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Intestine, Large / pathology
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Intestine, Small / pathology
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Lactoferrin / pharmacology*
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Male
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Rats
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Rats, Inbred F344
Substances
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Anticarcinogenic Agents
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Lactoferrin
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Azoxymethane