Beditine, a new benzodioxane derivative, as a suppressor of human polymorphonuclear leukocyte and platelet activation

Biochem Pharmacol. 1997 Jun 1;53(11):1753-5. doi: 10.1016/s0006-2952(97)82457-4.

Abstract

Beditine, 2-(2-amino-4-thiazolyl)-1,4-benzodioxane hydrochloride is a new substance which reduced platelet activation and degranulation, prevented aggregation and superoxide generation by activated human polymorphonuclear leukocytes (PMNL) and inhibited the activation of arachidonate 5-lipoxygenase. Beditine may, therefore, be a useful agent in the treatment of cardiovascular disease.

Publication types

  • Comparative Study

MeSH terms

  • Adenosine Triphosphate / metabolism
  • Aspirin / pharmacology
  • Calcimycin
  • Dioxanes / pharmacology*
  • Eicosanoids / biosynthesis
  • Humans
  • Lipoxygenase Inhibitors*
  • Neutrophils / drug effects*
  • Neutrophils / metabolism
  • Nifedipine / pharmacology
  • Platelet Aggregation Inhibitors / pharmacology*
  • Superoxides / metabolism
  • Thiazoles / pharmacology*

Substances

  • Dioxanes
  • Eicosanoids
  • Lipoxygenase Inhibitors
  • Platelet Aggregation Inhibitors
  • Thiazoles
  • beditine
  • Superoxides
  • Calcimycin
  • Adenosine Triphosphate
  • Nifedipine
  • Aspirin