Abstract
Structures of the O-specific polysaccharide chains of lipopolysaccharides from Proteus group OX strains (serogroups O1-O3) used as antigens in Weil-Felix test for diagnosis of rickettsiosis, were established. From them, the acid-labile polysaccharide of Proteus vulgaris OX19 (O1) is built up of the following branched pentasaccharide repeating units connected via a phosphate group: [structure in text] where QuiNAc stands for 2-acetamido-2,6-dideoxyglucose (N-acetylquinovosamine). The basis of serospecificity of the Proteus group OX antigens and their cross-reactivity with human anti-rickettsial antibodies is discussed.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Antibodies, Bacterial / immunology
-
Carbohydrate Conformation
-
Carbohydrate Sequence
-
Cross Reactions
-
Humans
-
Magnetic Resonance Spectroscopy
-
Molecular Sequence Data
-
Monosaccharides / analysis
-
O Antigens / chemistry*
-
O Antigens / immunology
-
Oligosaccharides / chemistry
-
Proteus mirabilis / classification
-
Proteus mirabilis / immunology*
-
Proteus vulgaris / classification
-
Proteus vulgaris / immunology*
-
Rickettsia / immunology
-
Rickettsia Infections / diagnosis
-
Rickettsia Infections / immunology
-
Serologic Tests
-
Sugar Phosphates / chemistry
Substances
-
Antibodies, Bacterial
-
Monosaccharides
-
O Antigens
-
Oligosaccharides
-
Sugar Phosphates