Abstract
We evaluated the renal effects of the new angiotensin II type 1 (AT ) receptor antagonist, HR 720, in the stroke-prone spontaneously hypertensive rat. Rats were treated with either vehicle, HR 720, MK-954 (a selective AT1 receptor antagonist) or enalapril for 6 weeks. Blood pressure was decreased to a similar extent by HR 720, MK-954 and enalapril (203 +/- 4, 202 +/- 5 and 190 +/- 4 vs. 247 +/- 4 mm Hg for control). Urinary protein secretion was also decreased (5.2 +/- 0.3, 5.3 +/- 0.2 and 5.5 +/- 0.6 vs. 25.2 +/- 4.6 mg/100g/24h). The glomerular hypertensive change was improved in each drug-treated group (2.0 +/- 0.2, 3.3 +/- 0.3 and 1.6 +/- 0.1 vs. 17.6 +/- 1.5%; p < 0.0001). These results show that, in addition to its antihypertensive effect, HR 720 has a beneficial effect on renal function.
MeSH terms
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Angiotensin I / antagonists & inhibitors
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Angiotensin I / metabolism
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Angiotensin II / antagonists & inhibitors*
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Angiotensin II / metabolism
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Angiotensin Receptor Antagonists
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Animals
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Biphenyl Compounds / pharmacology*
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Blood Pressure / drug effects
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Body Weight / drug effects
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Cerebrovascular Disorders / genetics
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Cerebrovascular Disorders / physiopathology
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Dose-Response Relationship, Drug
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Heart Rate / drug effects
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Hypertension / genetics
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Hypertension / physiopathology*
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Imidazoles / pharmacology*
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Kidney / drug effects*
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Kidney Function Tests
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Kidney Glomerulus / drug effects
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Kidney Glomerulus / ultrastructure
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Losartan
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Organ Size / drug effects
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Proteinuria / drug therapy
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Proteinuria / urine
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Rats
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Rats, Inbred SHR
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Receptors, Angiotensin / metabolism
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Tetrazoles / pharmacology
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Tissue Embedding
Substances
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Angiotensin Receptor Antagonists
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Biphenyl Compounds
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Imidazoles
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Receptors, Angiotensin
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Tetrazoles
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fonsartan
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Angiotensin II
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Angiotensin I
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Losartan