TEL/AML1 fusion gene resulting from a cryptic t(12;21) is uncommon in adult patients with B-cell lineage ALL and CML lymphoblastic transformation

K Hoshino; N Asou; H Suzushima; M Osato; H Yamasaki; T Okubo; S Nishimura; T Kiyokawa; F Kawano; K Takatsuki

doi:10.1016/s0925-5710(97)00036-4

TEL/AML1 fusion gene resulting from a cryptic t(12;21) is uncommon in adult patients with B-cell lineage ALL and CML lymphoblastic transformation

Int J Hematol. 1997 Aug;66(2):213-8. doi: 10.1016/s0925-5710(97)00036-4.

Authors

K Hoshino¹, N Asou, H Suzushima, M Osato, H Yamasaki, T Okubo, S Nishimura, T Kiyokawa, F Kawano, K Takatsuki

Affiliation

¹ Second Department of Internal Medicine, Kumamoto University School of Medicine, Japan.

PMID: 9277052
DOI: 10.1016/s0925-5710(97)00036-4

Abstract

TEL is a new member of the ETS-like family on chromosome 12 and forms fusion genes with several partners in leukemia. Among these fusion genes, the TEL/AML1 translocation resulting from t(12;21) is found in approximately one quarter of the childhood B-cell lineage acute lymphoblastic leukemia (ALL) cases and its prognosis is excellent. We examined 42 adult patients with B-cell lineage ALL and 13 adult patients with lymphoblastic transformation of chronic myeloid leukemia (CML) to detect TEL/AML1 fusion genes using the reverse transcriptase-polymerase chain reaction (RT-PCR) and Southern blotting, but no translocation was detected. These findings indicate that absence of the TEL/AML1 fusion transcript partly correlates with the poorer outcome of adult B-cell lineage ALL as compared with childhood ALL and the TEL/AML1 fusion transcript is specific for pediatric B-cell lineage ALL.

Publication types

Comparative Study
Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Adult
Age Factors
Aged
Animals
Biomarkers, Tumor / analysis
Biomarkers, Tumor / genetics*
Blast Crisis / genetics*
Blast Crisis / mortality
Blast Crisis / pathology
Burkitt Lymphoma / genetics*
Burkitt Lymphoma / mortality
Cell Transformation, Neoplastic / genetics
Child
Chromosomes, Human, Pair 12 / genetics*
Chromosomes, Human, Pair 12 / ultrastructure
Chromosomes, Human, Pair 21 / genetics*
Chromosomes, Human, Pair 21 / ultrastructure
Core Binding Factor Alpha 2 Subunit
Gene Expression Regulation, Leukemic
Gene Frequency
Humans
Leukemia, Myelogenous, Chronic, BCR-ABL Positive / genetics*
Leukemia, Myelogenous, Chronic, BCR-ABL Positive / mortality
Leukemia, Myelogenous, Chronic, BCR-ABL Positive / pathology
Middle Aged
Neoplasm Proteins / analysis
Neoplasm Proteins / genetics*
Neoplasm Proteins / physiology
Oncogene Proteins, Fusion*
Prognosis
Translocation, Genetic*

Substances

Biomarkers, Tumor
Core Binding Factor Alpha 2 Subunit
Neoplasm Proteins
Oncogene Proteins, Fusion
TEL-AML1 fusion protein