The aim of this study was to evaluate the clinical and biochemical characteristics and the different types of treatment of diabetic patients in hemodialysis (HD) due to their end-stage renal disease (ESRD). The protocol was organized as a multicentric, case-control study and comprised twenty-nine HD centres from the city and province of Buenos Aires (PRODIHEM). The population sample included all diabetic patients in HD (n = 103) and the non diabetic patients hemodialyzed in the morning hours (n = 230) as controls. In this sample, the recorded prevalence for diabetes mellitus was 12%. Among diabetic patients, 61% were non insulin dependent, 23% were insulin dependent and 16% were of the non insulin dependent type treated with insulin (Fig. 1). The results obtained in this study show that the current situation of diabetic patients in HD is far from being satisfactory: they require HD treatment at an early age; the disease is commonly associated with various comorbid factors not always appropriately treated; they show a fast deleterious progress towards ESRD, and they have a short halflife period in HD. The results also showed that there are no defined and common criteria for the treatment and control of these patients; thus, due to their poor clinical performance, only a small percentage reach a priority for a renal transplant.