Abstract
Recent work on CD1 molecules has demonstrated that human CD1b and a lipoglycan from mycobacteria that CD1b presents colocalize to late endosomes. Presentation of this lipoglycan by CD1b requires antigen uptake via the mannose receptor. CD8(+) CD1-restricted T cells can decrease the load of intracellular mycobacteria by granule release. TCR-transgenic and CD1-deficient mice have provided insights into the role of CD1 in the T helper responses required for the clearance of some microorganisms.
Publication types
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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Antigen Presentation / immunology*
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Antigens, Bacterial / immunology
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Antigens, CD1 / physiology*
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Antigens, Protozoan / immunology
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CD8-Positive T-Lymphocytes / immunology
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Endosomes / immunology
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Humans
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Infections / immunology*
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Leishmaniasis / immunology
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Lipopolysaccharides / immunology
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Mice
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Mice, Transgenic
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Mycobacterium / immunology
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Mycobacterium Infections / immunology
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Receptors, Antigen, T-Cell / deficiency
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Receptors, Antigen, T-Cell / immunology
Substances
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Antigens, Bacterial
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Antigens, CD1
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Antigens, Protozoan
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Lipopolysaccharides
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Receptors, Antigen, T-Cell