In vitro and in vivo properties of murine monoclonal antibody for a novel immature thymocyte-differentiated antigen, JL1

Nucl Med Biol. 1997 Jul;24(5):433-7. doi: 10.1016/s0969-8051(97)00026-7.

Abstract

JL1 is a novel thymocyte-differentiated antigen strictly confined to stage II immature cortical thymocytes. It is expressed in several types of leukemias and lymphomas. Murine anti-JL1 monoclonal antibody labeled with 131I and 99mTc showed 60-70% of immunoreactivity and 1.4-1.9 x 10(9) L/mol of affinity constant. The incubation of the radiolabeled antibody with Molt-4 cells showed no evidence of modulation or shedding. Localization indices increased from day 3 to day 5 in SCID mice bearing Molt-4 cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antibodies, Monoclonal* / immunology
  • Antibodies, Monoclonal* / pharmacokinetics
  • Antigens, Differentiation, T-Lymphocyte / analysis*
  • Antigens, Differentiation, T-Lymphocyte / immunology
  • Hematologic Neoplasms / diagnostic imaging*
  • Iodine Radioisotopes
  • Male
  • Mice
  • Mice, Inbred BALB C
  • Mice, SCID
  • Radioimmunodetection*
  • Technetium

Substances

  • Antibodies, Monoclonal
  • Antigens, Differentiation, T-Lymphocyte
  • Iodine Radioisotopes
  • JL1 antigen
  • Technetium