Abstract
Adhesion molecules participate in a broad variety of biological processes, i.e. tumour progression and inflammation, through their involvement in cell-to-cell interactions and immunoinflammatory cell migration. This review describes the basic properties of adhesion molecules with reference to inflammatory bowel disease and colorectal carcinoma. Future therapeutic approaches in inflammatory and malignant disorders may include development of principles targeting adhesion molecules.
MeSH terms
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Annexins / metabolism
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Cadherins / metabolism
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Cell Adhesion Molecules / immunology
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Cell Adhesion Molecules / metabolism
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Cell Adhesion Molecules / physiology*
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Colonic Neoplasms / drug therapy
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Colonic Neoplasms / etiology
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Colonic Neoplasms / immunology*
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Humans
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Immunoglobulins / metabolism
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Inflammatory Bowel Diseases / drug therapy
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Inflammatory Bowel Diseases / etiology
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Inflammatory Bowel Diseases / immunology*
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Integrins / metabolism
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Rectal Neoplasms / drug therapy
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Rectal Neoplasms / etiology
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Rectal Neoplasms / immunology*
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Selectins / metabolism
Substances
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Annexins
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Cadherins
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Cell Adhesion Molecules
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Immunoglobulins
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Integrins
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Selectins