Abstract
The presence of tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) activities was determined in milk and serum of cows with naturally occurring coliform mastitis (CFM). TNF-alpha was detected in the sera from 26 of 32 cows with CFM. TNF-alpha levels were higher in the sera than in the milk. IL-6 was high in the sera of surviving CFM animals, but was low in animals that died and in healthy controls. Furthermore, the mean level of IL-6 was 20-fold higher in the milk than in the sera of mastitic cows. The level of IL-6 in the serum was correlated to that in the milk in individual animals. The presence of IL-6 and TNF-alpha in the sera appears to relate to severe clinical condition of CFM, in the milk whereas they may play a role in generating inflammation of the mammary gland.
MeSH terms
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Animals
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Cattle
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Cattle Diseases / blood
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Cattle Diseases / metabolism
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Enterobacter / isolation & purification
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Enterobacteriaceae Infections / blood
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Enterobacteriaceae Infections / metabolism
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Enterobacteriaceae Infections / veterinary*
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Escherichia coli / isolation & purification
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Escherichia coli Infections / blood
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Escherichia coli Infections / metabolism
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Escherichia coli Infections / veterinary
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Female
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Interleukin-6 / analysis*
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Interleukin-6 / blood*
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Klebsiella / isolation & purification
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Klebsiella Infections / blood
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Klebsiella Infections / metabolism
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Klebsiella Infections / veterinary
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Mastitis, Bovine / blood
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Mastitis, Bovine / metabolism*
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Mastitis, Bovine / microbiology
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Milk / chemistry*
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Milk / microbiology
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Tumor Necrosis Factor-alpha / analysis*
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Tumor Necrosis Factor-alpha / metabolism
Substances
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Interleukin-6
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Tumor Necrosis Factor-alpha