Abstract
To study the role of the sixth member of the FGF (fibroblast growth factor) family whose expression is restricted to skeletal muscle, we have derived mouse mutants with a homozygous disruption of the Fgf6 gene. The animals are viable, fertile and apparently normal, indicating that FGF6 is not required for vital functions in the laboratory mouse.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Blastocyst / metabolism
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Blotting, Southern
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Embryonic and Fetal Development
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Female
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Fibroblast Growth Factor 6
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Fibroblast Growth Factors*
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Gene Targeting / methods
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Genetic Vectors
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Genotype
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Homozygote
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Lac Operon / genetics
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Male
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Mice
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Mice, Knockout
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Muscle, Skeletal / embryology
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Muscle, Skeletal / physiology*
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Phenotype
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Polymerase Chain Reaction
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Proto-Oncogene Proteins / deficiency
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Proto-Oncogene Proteins / genetics*
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Proto-Oncogene Proteins / physiology
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Recombination, Genetic
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Stem Cells / metabolism
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Transfection
Substances
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Fgf6 protein, mouse
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Fibroblast Growth Factor 6
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Proto-Oncogene Proteins
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Fibroblast Growth Factors