Abstract
Four new botrydial derivatives, hymendial (1), 7 alpha-hydroxydihydrobotrydial (2), 7 alpha-hydroxy-10-O-methyldihydrobotrydial (4), and 7 alpha-acetoxy-15 alpha-methoxy-10-O-methyl-dihydrobotrydial (5) were isolated together with dihydrobotrydial (3) from the culture fluid of the ascomycete Hymenoscyphus epiphyllus. In addition, cytochalasin H (6a), 18-deoxycytochalasin H (6b) and (+)-mellein (7) were produced by this fungus. Hymendial (1), possessing an alpha, beta-unsaturated dialdehyde functionality, exhibits antimicrobial and cytotoxic activities and is mutagenic in the Ames Salmonella assay.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Animals
-
Antineoplastic Agents / chemistry*
-
Antineoplastic Agents / isolation & purification
-
Antineoplastic Agents / toxicity
-
Ascomycota / chemistry*
-
Ascomycota / growth & development
-
Cell Line
-
Cell Survival / drug effects*
-
Fermentation
-
HeLa Cells
-
Humans
-
Leukemia L1210
-
Mice
-
Microbial Sensitivity Tests
-
Molecular Structure
-
Nuclear Magnetic Resonance, Biomolecular
-
Salmonella typhimurium / drug effects
-
Sesquiterpenes / chemistry*
-
Sesquiterpenes / isolation & purification
-
Sesquiterpenes / pharmacology
-
Tumor Cells, Cultured
Substances
-
Antineoplastic Agents
-
Sesquiterpenes