Abstract
To determine the relationship between breast cancer progression and gene amplification, we screened 62 distant metastases and 122 primary breast tumours for the amplification of the proto-oncogenes MYC and ERBB2 and the 11q13 chromosomal region. Surprisingly, solid metastases showed an absence of gene amplification. These results suggest that the amplification of the proto-oncogenes MYC and ERBB2 and the 11q13 chromosomal region seem to be involved mainly in the genesis of the primary breast tumour rather than its progression.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Breast Neoplasms / genetics*
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Breast Neoplasms / pathology
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Chromosomes, Human, Pair 11
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DNA, Neoplasm / genetics*
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Fibroblast Growth Factor 3
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Fibroblast Growth Factors / genetics
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Gene Amplification*
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Genes, erbB-2*
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Genes, mos
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Genes, myc*
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Humans
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Neoplasm Metastasis
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Pleural Effusion
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Proto-Oncogene Proteins / genetics
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Receptor, ErbB-2 / genetics*
Substances
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DNA, Neoplasm
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FGF3 protein, human
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Fibroblast Growth Factor 3
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Proto-Oncogene Proteins
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Fibroblast Growth Factors
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Receptor, ErbB-2