Hypersensitivity reactions to cisplatin following multiple uncomplicated courses: a report on two cases

J Obstet Gynaecol Res. 1997 Aug;23(4):347-52. doi: 10.1111/j.1447-0756.1997.tb00856.x.

Abstract

Two patients with ovarian cancer who had received multiple courses of cisplatin without complications experienced hypersensitivity reactions to cisplatin: one, involving intrahepatic artery infusion, manifested general erythema, dyspnea, and hypotension; the other, involving intravenous infusion, manifested abdominal pain, general erythema, and fever. When platinum-containing agents are administered, patients should be closely monitored for hypersensitivity reactions, even in previously uncomplicated cases.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antineoplastic Agents / administration & dosage
  • Antineoplastic Agents / adverse effects*
  • Antineoplastic Agents / therapeutic use
  • Cisplatin / administration & dosage
  • Cisplatin / adverse effects*
  • Cisplatin / therapeutic use
  • Drug Hypersensitivity / etiology*
  • Drug Hypersensitivity / physiopathology
  • Female
  • Humans
  • Infusions, Intra-Arterial
  • Infusions, Intravenous
  • Middle Aged
  • Ovarian Neoplasms / drug therapy*
  • Radiation-Sensitizing Agents / administration & dosage
  • Radiation-Sensitizing Agents / adverse effects*
  • Radiation-Sensitizing Agents / therapeutic use

Substances

  • Antineoplastic Agents
  • Radiation-Sensitizing Agents
  • Cisplatin