The management of acute myocardial infarction (AMI) has undergone major changes in the last decade. Today clinical practice can be based on sound evidence derived from a large number of well-conducted, randomized, large-scale clinical trials. Because of this, Scientific Societies, such as the European Society of Cardiology, have recently produced evidence-based guidelines for the treatment of AMI. This article summarizes the up-to-date, evidence-based treatments for patients with AMI, and their limitations in terms of uncertainty and transferability to real populations.