The aim of the present study was to present the results after endoscopic carpal tunnel release in the first 30 hands operated in our department. Over a five month period we used the Agee one-portal system for endoscopic carpal tunnel release in all patients operated with a carpal tunnel release in our department. All patients were operated by one surgeon, who recorded all data and results prospectively. The patients were evaluated preoperatively and after two and eight weeks. A total of 30 hands in 25 patients were operated. There were 19 females and six males with a mean age of 50.1 years (23-80). There were no haematomas, injuries to the arcade vessels, nerve lesions or infections. All patients but one stated a good clinical result of the operation, and all patients had regained normal movement of all fingers at the two-week postoperative check-up. All patients, who were working preoperatively, were able to return to work after two to three weeks except for three patients. In conclusion, we have not experienced any complications in our series, and all patients but one had a good clinical results. We feel that the Agee one-portal system ensures carpal tunnel release with a minimum of discomfort, and we find the preliminary results in our department so promising, that we now use this technique as a routine in uncomplicated cases of carpal tunnel syndrome.