Human immunodeficiency virus type 2 envelope glycoprotein binds to CD8 as well as to CD4 molecules on human T cells

H Kaneko; L P Neoh; N Takeda; H Akimoto; T Hishikawa; H Hashimoto; S Hirose; S Karaki; M Takiguchi; H Nakauchi; Y Kaneko; N Yamamoto; I Sekigawa

doi:10.1128/JVI.71.11.8918-8922.1997

Human immunodeficiency virus type 2 envelope glycoprotein binds to CD8 as well as to CD4 molecules on human T cells

J Virol. 1997 Nov;71(11):8918-22. doi: 10.1128/JVI.71.11.8918-8922.1997.

Authors

H Kaneko¹, L P Neoh, N Takeda, H Akimoto, T Hishikawa, H Hashimoto, S Hirose, S Karaki, M Takiguchi, H Nakauchi, Y Kaneko, N Yamamoto, I Sekigawa

Affiliation

¹ Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine, Tokyo, Japan.

Abstract

We report here that human immunodeficiency virus type 2 (HIV-2) envelope glycoprotein (gp105), but not HIV-1 gp120, can bind to CD8 molecules as well as to CD4 molecules on human T cells. This phenomenon may lead to differences in the life cycles of HIV-1 and HIV-2, and it may be related to the differences in disease manifestations of HIV-1 and HIV-2 infection, including longer survival of HIV-2-infected patients.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

CD4 Antigens / metabolism*
CD4-Positive T-Lymphocytes / virology*
CD8 Antigens / metabolism*
CD8-Positive T-Lymphocytes / virology*
Cell Line
Gene Products, env / metabolism*
HIV Envelope Protein gp120 / metabolism
HIV-2 / metabolism*
Humans
Protein Binding
Receptors, HIV / metabolism*
env Gene Products, Human Immunodeficiency Virus

Substances

CD4 Antigens
CD8 Antigens
Gene Products, env
HIV Envelope Protein gp120
Receptors, HIV
env Gene Products, Human Immunodeficiency Virus
gp105 envelope protein, Human immunodeficiency virus 2