Abstract
We have identified a novel human gene with strong homology to the mouse Pa2g4 cell cycle gene. This novel gene (called PA2G4) belongs to a gene family with members in several chromosome regions: 3q24-q25, 6q22, 9q21, 12q13, 18q12, 20p12 and Xq25. A composite cDNA of 1697 nucleotides was isolated. The sequence of this cDNA predicts a protein of 394 amino acids. The deduced amino acid sequence of this human protein shows very strong homology to the mouse protein p38-2G4. The cDNA analyzed probably corresponds to a functional copy found at 12q13.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Base Sequence
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Blotting, Northern
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Cell Cycle / genetics*
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Chromosome Banding
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Chromosome Mapping
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Chromosomes, Human, Pair 12
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Chromosomes, Human, Pair 20
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Chromosomes, Human, Pair 3
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Chromosomes, Human, Pair 6
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Chromosomes, Human, Pair 9
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Cloning, Molecular
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DNA, Complementary / isolation & purification
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DNA-Binding Proteins
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Female
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Humans
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Intestines / chemistry
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Leukocytes / chemistry
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Male
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Mice
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Molecular Sequence Data
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Nuclear Proteins / genetics*
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Ovary / chemistry
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Prostate / chemistry
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Pseudogenes
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RNA, Messenger / analysis
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RNA-Binding Proteins
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Sequence Homology, Amino Acid
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Spleen / chemistry
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Testis / chemistry
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X Chromosome
Substances
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DNA, Complementary
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DNA-Binding Proteins
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Nuclear Proteins
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Pa2g4 protein, mouse
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RNA, Messenger
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RNA-Binding Proteins