HLA class II allele frequencies in northern Thais (Kamphaeng Phet)

R Maneemaroj; H A Stephens; D Chandanayingyong; K Longta; S Bejrachandra

HLA class II allele frequencies in northern Thais (Kamphaeng Phet)

J Med Assoc Thai. 1997 Sep:80 Suppl 1:S20-4.

Authors

R Maneemaroj¹, H A Stephens, D Chandanayingyong, K Longta, S Bejrachandra

Affiliation

¹ Department of Pathology, Pramongkutklao College of Medicine, Bangkok, Thailand.

PMID: 9347641

Abstract

The polymorphism of HLA class II genes (HLA-DRB1, -DQA1, -DQB1 and -DPB1) was investigated in 97 normal Northern Thais (NT) from Kamphaeng Phet province using PCR-SSO typing. Allele frequencies (AF) have been determined. DRB1*1202 (17.5%), DRB1*1502 (16.5%), DQA1*0101 (25.8%), DQA1*0102 (21.7%), DQB1*0502 (22.7%), DPB1*0501 (23.2%) and DPB1*1301 (22.7%) showed the highest frequencies in each locus. These results were more similar to those observed in Present-day Thais (PDT) and Central Thais (CT) than Northern Thais from Chiang Mai (CM) and Dai Lue (DL). However, the data presented in this population study should be useful in many fields, such as anthropology, organ transplantation, disease susceptibility and evolutionary genetics.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alleles*
Ethnicity / genetics*
Gene Frequency*
HLA Antigens / genetics*
Humans
Polymerase Chain Reaction / methods
Polymorphism, Genetic
Thailand

Substances

HLA Antigens