Functionalized analogues of 5,8,10-trideazafolate as potential inhibitors of GAR Tfase or AICAR Tfase

Bioorg Med Chem. 1997 Sep;5(9):1831-8. doi: 10.1016/s0968-0896(97)00121-1.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Cell Division / drug effects
  • Enzyme Inhibitors / pharmacology*
  • Glutamates / chemistry
  • Glutamates / pharmacology*
  • Humans
  • Hydroxymethyl and Formyl Transferases / antagonists & inhibitors*
  • Magnetic Resonance Spectroscopy
  • Molecular Structure
  • Phosphoribosylaminoimidazolecarboxamide Formyltransferase
  • Phosphoribosylglycinamide Formyltransferase
  • Quinazolines / chemistry
  • Quinazolines / pharmacology*
  • Spectrometry, Mass, Fast Atom Bombardment
  • Tumor Cells, Cultured

Substances

  • Enzyme Inhibitors
  • Glutamates
  • Quinazolines
  • Hydroxymethyl and Formyl Transferases
  • Phosphoribosylglycinamide Formyltransferase
  • Phosphoribosylaminoimidazolecarboxamide Formyltransferase