Lack of apolipoprotein E dramatically reduces amyloid beta-peptide deposition

Nat Genet. 1997 Nov;17(3):263-4. doi: 10.1038/ng1197-263.
No abstract available

Publication types

  • Letter

MeSH terms

  • Age Factors
  • Alzheimer Disease / genetics
  • Alzheimer Disease / physiopathology*
  • Amyloid beta-Peptides / genetics
  • Amyloid beta-Peptides / immunology
  • Amyloid beta-Peptides / metabolism*
  • Amyloid beta-Protein Precursor / genetics
  • Animals
  • Apolipoproteins E / genetics*
  • Apolipoproteins E / metabolism
  • Brain / metabolism
  • Brain / pathology*
  • Humans
  • Immunohistochemistry
  • Mice
  • Mice, Inbred C57BL
  • Mice, Inbred DBA
  • Mice, Knockout
  • Mice, Transgenic
  • Polymerase Chain Reaction
  • RNA, Messenger / biosynthesis

Substances

  • Amyloid beta-Peptides
  • Amyloid beta-Protein Precursor
  • Apolipoproteins E
  • RNA, Messenger