Abstract
The scavenger receptor cysteine-rich (SRCR) superfamily, which includes proteins expressed by leukocytes, can be subdivided into groups A and B. Group B contains the lymphocyte cell-surface receptor CD6. This article reviews recent progress in understanding the interaction between CD6 and its ligand, activated leukocyte cell adhesion molecule (ALCAM). Analysis of the CD6-ALCAM interaction may help to understand how other SRCR domains bind to their ligands.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Activated-Leukocyte Cell Adhesion Molecule
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Amino Acid Sequence
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Animals
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Antigens, CD / immunology*
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Antigens, Differentiation, T-Lymphocyte / immunology*
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Cell Adhesion Molecules / immunology
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Glycoproteins / immunology
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Humans
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Ligands
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Membrane Proteins*
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Models, Molecular
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Molecular Sequence Data
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Receptors, Cell Surface / chemistry
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Receptors, Cell Surface / genetics
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Receptors, Cell Surface / immunology*
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Receptors, Immunologic*
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Receptors, Lipoprotein*
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Receptors, Scavenger
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Scavenger Receptors, Class B
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Sequence Homology, Amino Acid
Substances
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Activated-Leukocyte Cell Adhesion Molecule
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Antigens, CD
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Antigens, Differentiation, T-Lymphocyte
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CD6 antigen
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Cell Adhesion Molecules
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Glycoproteins
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Ligands
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Membrane Proteins
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Receptors, Cell Surface
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Receptors, Immunologic
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Receptors, Lipoprotein
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Receptors, Scavenger
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Scarb1 protein, mouse
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Scavenger Receptors, Class B