Expression of three rare fragile sites: chromosomal truncation, amplification of distal segment and telomeric renewal

N Villa; L Dalprà; L Larizza

doi:10.1007/s004120050261

Expression of three rare fragile sites: chromosomal truncation, amplification of distal segment and telomeric renewal

Chromosoma. 1997 Nov;106(6):400-4. doi: 10.1007/s004120050261.

Authors

N Villa¹, L Dalprà, L Larizza

Affiliation

¹ Department of Biology and Genetics, Medical Faculty, University of Milan, Via Viotti 3/5, I-20133 Milan, Italy.

PMID: 9362548
DOI: 10.1007/s004120050261

Abstract

Fluorescence in situ hybridization with a telomeric probe was used to monitor telomeric renewal following breakage induced by the rare fragile sites FRA10A, FRA12A and FRA16B. Interstitial telomere-like sequences were detected only at the break sites of FRA10A.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Chromosome Aberrations / genetics*
Chromosome Deletion
Chromosome Disorders
Chromosome Fragile Sites
Chromosome Fragility*
Chromosomes, Human, Pair 10
Chromosomes, Human, Pair 12
Chromosomes, Human, Pair 16
DNA Probes
Female
Humans
In Situ Hybridization, Fluorescence
Infant, Newborn
Male
Telomere / genetics*

Substances

DNA Probes