Assignment of the human cardiac/slow skeletal muscle troponin C gene (TNNC1) between D3S3118 and GCT4B10 on the short arm of chromosome 3 by somatic cell hybrid analysis

P J Townsend; M H Yacoub; P J Barton

doi:10.1046/j.1469-1809.1997.6140375.x

Assignment of the human cardiac/slow skeletal muscle troponin C gene (TNNC1) between D3S3118 and GCT4B10 on the short arm of chromosome 3 by somatic cell hybrid analysis

Ann Hum Genet. 1997 Jul;61(Pt 4):375-7. doi: 10.1046/j.1469-1809.1997.6140375.x.

Authors

P J Townsend¹, M H Yacoub, P J Barton

Affiliation

¹ Imperial College School of Medicine, National Heart and Lung Institute, London.

PMID: 9365790
DOI: 10.1046/j.1469-1809.1997.6140375.x

Abstract

We have determined the chromosomal location of the human cardiac/slow skeletal muscle troponin C gene (TNNC1) to the short arm of chromosome 3 using somatic cell hybrids. PCR-based analysis of a 'monochromosomal' hybrid panel identified the presence of the TNNC1 gene on human chromosome 3 and subsequent analysis of the Genebridge4 radiation hybrid panel located the gene between D3S3118 (7.3cR) and GCT4B10 (4.2cR) with a lod score of > 3.0.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Chromosome Mapping*
Chromosomes, Human, Pair 3 / genetics*
Genes / genetics
Humans
Hybrid Cells
Lod Score
Troponin C / genetics*

Substances

Troponin C