Abstract
A model sterol-based ion channel was rationally designed and synthesized. The potential ion channel is comprised of a tartrate-derived crown ether to which six steroids are appended. Macromolecule 1a was incorporated into phospholipid vesicles and shown to facilitate the transmembrane transport of sodium and lithium ions using alkali metal NMR spectroscopy.
Publication types
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Comparative Study
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Ethers, Cyclic / chemistry
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Ion Channels / chemical synthesis*
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Ion Channels / chemistry
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Ion Channels / metabolism*
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Lipid Bilayers / chemistry
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Lipid Bilayers / metabolism
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Magnetic Resonance Spectroscopy
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Phosphatidylcholines / chemistry
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Sterols / chemistry*
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Tartrates / chemistry
Substances
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Ethers, Cyclic
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Ion Channels
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Lipid Bilayers
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Phosphatidylcholines
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Sterols
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Tartrates
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tartaric acid