In order to find out the perniciousness of Toxo infection in pregnant women and to adopt proper intervention measures, we carried out a seroepidemiologic survey of Anti-Toxo-IgM with Capture-EIA in pregnant women who were given perintal medical care in Henan province. The positive rate of Anti Toxo-IgM was 3.38% among 4,126 pregnant women. A follow-up survey showed that abnormal birth rate was 8.20% in those infected women. We tried intervention at birth in six infected women including four on an initiative termination of pregnancy. Among the two who insisted in heeping pregnant, one neonate died of unusual delivery. Based on the study findings, sero-epidemiologic survey in pregnant women shows an important significance in better child-bearing.