The clinical data of 100 female cases with suspected coronary heart disease (CHD) undergoing coronary artery angiography (CAA) were analysed. CHD was defined as an estimated diameter stenosis of 75% and more in the main coronary arteries or coronary stenosis of 50%-75% with evidence of cardiac ischemia. Forty-eight case were confirmed as having CHD by CAA. The remaining 52 cases were confirmed as non-CHD and served as the control group, including 49 cases with normal coronary arteries and 3 cases with stenosis of less than 50% in the right coronary artery or left anterior descending artery. The risk factors of CHD and clinical characteristics of chest pain were compared for the two groups. The data demonstrated that menopause was a special risk factor for females and the incidence of CHD was increasing with aging after menopause. However, the clinical characteristics of chest pain in female CHD were usually atypical. When chest pain, whether clinically typical or atypical, were present after menopause and accompanied by evident risk factors, the probability of CHD would be high. If there was only chest pain without any risk factor after menopause, the diagnosis of CHD would be less likely.