In order to study etiology of blackfoot disease in Taiwan and to explore whether it can occur in the area with arsenosis in Inner Mongolia in the future, chemical components of specimens of drinking water from Taiwan and Inner Mongolia were determined and compared with infrared (IR), ultra-violet (UV) spectrometry and fluorescence spectrometry. Humic acid was extracted from the water samples by XAD-7 ion-exchange resin and Sephadex G-25 gel filtration chromatography, respectively, yielding the same results. Studies showed arsenic and humic acid levels in water samples both from Taiwan and Inner Mongolia all were higher, and their fluorescence and UV-spectra were similar, except a small difference in their IR spectra. Their effects on environment are under further studies.