Abstract
Paramyosin from parasitic worms of the genus Schistosoma has shown promise as a vaccine target and it is one of the candidates selected by WHO for the development of a vaccine against schistosomiasis. Here we discuss the literature of the past decade and report on different recombinant paramyosin constructs we are using in our laboratory to develop a vaccine against the Asian schistosoma, Schistosoma japonicum.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Amino Acid Sequence
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Animals
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Antigens, Helminth / genetics
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Helminth Proteins / genetics
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Helminth Proteins / immunology
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Humans
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Molecular Sequence Data
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Recombinant Proteins / genetics
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Recombinant Proteins / immunology
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Schistosoma japonicum / genetics
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Schistosoma japonicum / immunology*
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Schistosomiasis japonica / immunology
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Schistosomiasis japonica / prevention & control*
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Tropomyosin / genetics
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Tropomyosin / immunology*
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Vaccines, Synthetic / isolation & purification*
Substances
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Antigens, Helminth
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Helminth Proteins
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Recombinant Proteins
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Tropomyosin
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Vaccines, Synthetic