Abstract
We describe three patients who developed fundic gland polyps after starting a treatment with acid suppressive agents. All three patients were treated for a long time with H2-blockers or proton pump inhibiting agents for reflux oesophagitis. In one patient the fundic gland polyps disappeared after discontinuation of the acid suppressing therapy. A possible causal role of these agents is suggested. A review of the literature about fundic gland polyps and their possible association with acid suppressive therapy and a short review about proton pump inhibiting agents and the appearance of gastric polyps in general is given.
MeSH terms
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Aged
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Aged, 80 and over
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Anti-Ulcer Agents / adverse effects*
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Anti-Ulcer Agents / therapeutic use
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Esophagitis, Peptic / diagnosis
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Esophagitis, Peptic / drug therapy*
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Esophagoscopy
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Female
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Fundoplication
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Gastric Acid / metabolism
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Gastric Fundus / pathology
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Gastroscopy
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Humans
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Male
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Omeprazole / adverse effects*
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Omeprazole / therapeutic use
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Polyps / chemically induced*
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Polyps / pathology
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Polyps / surgery
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Ranitidine / adverse effects*
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Ranitidine / therapeutic use
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Stomach Neoplasms / chemically induced*
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Stomach Neoplasms / pathology
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Stomach Neoplasms / surgery
Substances
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Anti-Ulcer Agents
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Ranitidine
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Omeprazole