Abstract
The Na+-dependent bile salt uptake systems Ntcp (rodents) and NTCP (human), and the Na+-independent organic anion transporters oatpl (rat) and OATP (human) mediate sinusoidal uptake of a variety of amphipathic organic compounds into hepatocytes. Their properties indicate that an overall hepatic clearance of albumin-bound compounds is mediated by a limited number of multispecific transporters with partially overlapping substrate specificities.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Anion Transport Proteins
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Anions / metabolism
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Bile Acids and Salts / metabolism
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Bile Acids and Salts / physiology
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Carrier Proteins / genetics
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Carrier Proteins / physiology*
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Cloning, Molecular
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Humans
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Liver / metabolism*
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Membrane Transport Proteins*
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Models, Molecular
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Organic Anion Transporters, Sodium-Dependent
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Rats
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Substrate Specificity
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Symporters
Substances
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Anion Transport Proteins
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Anions
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Bile Acids and Salts
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Carrier Proteins
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Membrane Transport Proteins
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Organic Anion Transporters, Sodium-Dependent
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Symporters
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sodium-bile acid cotransporter