Early radiologically proven rebleeding from intracranial cavernous angiomas: report of 6 cases and review of the literature

Acta Neurochir (Wien). 1997;139(10):914-22. doi: 10.1007/BF01411299.

Abstract

Although intracranial cavernomas are known to cause haemorrhage, data concerning the frequency, severity and delay of recurrent bleedings are controversial. We report a series of 6 patients with histologically proven cavernoma, presenting with early clinical signs and radiological proof of rebleeding, that is occurring in the first month after initial overt haemorrhage. These 6 cases have been selected from a series of 142 patients seen between 1980 and 1995 in our department with cavernous angiomas or so-called AOVMs, of whom 93 presented with clinical symptoms of haemorrhage (34 patients presented symptoms of one or more rebleeding, but only 6 had radiological proof). All patients suffered neurological worsening due to the rebleeding, with an increase of the size of the haematoma on the CT scan. Five MRIs were performed at the acute stage: 3 showed evidence of cavernoma (60%). All patients underwent surgery at the acute stage of the rebleeding, with 5 improvements and 1 stabilization. A cavernous angioma was found in 5 cases at first surgery, but a further operation was necessary in the last patient to find and remove the cavernoma, after a second rebleeding following the first intervention. Our series reveals a high frequency of rebleeding after a first intracranial haemorrhage from a cavernous angioma, and highlights the precocity of such rebleedings. Therefore, we advocate early aggressive surgical management: in cases of cavernoma revealed by a first clinical overt haemorrhage, when there is strong radiological suspicion at the acute stage; and in all cases of rebleeding, even without radiological evidence of malformation, in the absence of vascular risk factors. Surgical indication must be discussed in particular cases of cavernomas of the brain stem when neither the haematoma nor the cavernoma reach the surface, and in deep supratentorial cavernomas, when the neurological status is good, because of the therapeutic risk.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adolescent
  • Adult
  • Brain Neoplasms / diagnosis*
  • Brain Neoplasms / surgery
  • Cerebral Hemorrhage / diagnosis*
  • Cerebral Hemorrhage / surgery
  • Female
  • Hemangioma, Cavernous / diagnosis*
  • Hemangioma, Cavernous / surgery
  • Humans
  • Magnetic Resonance Imaging*
  • Male
  • Middle Aged
  • Neoplasm Recurrence, Local / diagnosis*
  • Neoplasm Recurrence, Local / surgery
  • Neurologic Examination
  • Postoperative Complications / diagnosis*
  • Postoperative Complications / surgery
  • Reoperation
  • Tomography, X-Ray Computed*
  • Treatment Outcome