Abstract
Forty-nine "standard" compounds known to be useful in the treatment of other diseases were tested for their suppressive activity against the trypomastigotes of Trypanosoma cruzi-infected mice. The most active was the antidepressant protriptyline, which was almost three times as effective as the reference drug, nifurtimox. A major value of the present data is to demonstrate the refractoriness of the T. cruzi parasite against many of the drug standards that have known biological activity.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antiprotozoal Agents / therapeutic use*
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Chagas Disease / drug therapy*
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Chagas Disease / parasitology
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Disease Models, Animal
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Female
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Imipramine / chemistry
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Imipramine / therapeutic use
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Ketoconazole / therapeutic use
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Mice
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Mice, Inbred Strains
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Nifurtimox / therapeutic use
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Nigericin / therapeutic use
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Niridazole / therapeutic use
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Protriptyline / chemistry
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Protriptyline / therapeutic use
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Trypanosoma cruzi / drug effects*
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Trypanosoma cruzi / growth & development
Substances
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Antiprotozoal Agents
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Protriptyline
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Nifurtimox
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Niridazole
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Imipramine
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Ketoconazole
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Nigericin