Abstract
The synthesis of a DNA-cutting agent that conjugates an ellipticine chromophore and a copper complex of bis(salicylidene)ethylenediamine, referred to as a salen, is reported. The presence of the salen.Cu complex allows cleavage of DNA via oxygen-based radicals, and the ellipticine moiety serves as a DNA anchor. Spectroscopic measurements indicate that the intercalation geometry of the ellipticine chromophore is preserved with the hybrid. The cleavage is much more efficient with the conjugate than with the Schiff base copper complex alone.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Chelating Agents / chemistry*
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Chelating Agents / metabolism*
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Chelating Agents / pharmacology
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Circular Dichroism
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Copper / chemistry*
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Copper / metabolism*
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Copper / pharmacology
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DNA / drug effects*
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DNA / metabolism*
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DNA Damage*
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Ellipticines / chemical synthesis*
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Ellipticines / metabolism*
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Ellipticines / pharmacology
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Ethylenediamines / chemistry*
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Ethylenediamines / metabolism*
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Ethylenediamines / pharmacology
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Organometallic Compounds / chemical synthesis*
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Organometallic Compounds / metabolism*
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Organometallic Compounds / pharmacology
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Spectrophotometry
Substances
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Chelating Agents
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Ellipticines
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Ethylenediamines
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Organometallic Compounds
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Copper
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DNA
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disalicylaldehyde ethylenediamine