Abstract
Parenteral administration of a mouse anti-human CD8 monoclonal antibody (MAb) to rhesus macaques resulted in a transient depletion of CD8+ cells in both the peripheral blood and lymphoid tissues. When administered during primary chimeric simian/human immunodeficiency virus infections, the CD8 MAb caused marked elevations of plasma and cell-associated virus levels in both the peripheral blood and lymphoid tissues and led to prolonged depletion of CD4 cells. Taken together, these results directly demonstrate that CD8+ T lymphocytes are actively involved in controlling the acute phase of primate lentivirus infections.
MeSH terms
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Animals
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Antibodies, Monoclonal / pharmacology*
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CD28 Antigens / immunology
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CD4-Positive T-Lymphocytes / immunology
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CD8 Antigens / immunology*
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CD8-Positive T-Lymphocytes / immunology
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Chimera / genetics
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Chimera / immunology
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HIV Infections / etiology
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HIV Infections / immunology
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HIV Infections / virology
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HIV-1 / genetics*
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HIV-1 / immunology*
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HIV-1 / isolation & purification
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Humans
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Lymphocyte Count
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Lymphocyte Depletion
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Macaca fascicularis
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Macaca mulatta
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Mice
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Simian Acquired Immunodeficiency Syndrome / etiology
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Simian Acquired Immunodeficiency Syndrome / immunology
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Simian Acquired Immunodeficiency Syndrome / virology
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Simian Immunodeficiency Virus / genetics*
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Simian Immunodeficiency Virus / immunology*
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Simian Immunodeficiency Virus / isolation & purification
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T-Lymphocyte Subsets / immunology
Substances
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Antibodies, Monoclonal
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CD28 Antigens
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CD8 Antigens