Abstract
Herpes simplex virus type 1 glycoproteins gB, gD, and gHgL were expressed by transient transfection of Cos cells. Polykaryocyte formation above the background level seen in untransfected controls was observed only if all three components were expressed. Thus, gB, gD, and gHgL are necessary and sufficient to induce membrane fusion.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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COS Cells
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Herpesvirus 1, Human / genetics
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Herpesvirus 1, Human / pathogenicity*
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Herpesvirus 1, Human / physiology
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Membrane Fusion / genetics
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Membrane Fusion / physiology*
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Mutation
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Transfection*
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Viral Envelope Proteins / genetics
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Viral Envelope Proteins / physiology*
Substances
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Viral Envelope Proteins
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glycoprotein B, Simplexvirus
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glycoprotein D, Human herpesvirus 1
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glycoprotein H, herpes simplex virus type 1
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glycoprotein L, Human herpesvirus 1