Clearance of an influenza A virus by CD4+ T cells is inefficient in the absence of B cells

J Virol. 1998 Jan;72(1):882-5. doi: 10.1128/JVI.72.1.882-885.1998.

Abstract

The primary CD8+ T-cell response protected most B-cell-deficient muMT mice against intranasal infection with the HKx31 influenza A virus. Prior exposure did not prevent reinfection upon homologous challenge, and the recall CD8+ T-cell response cleared the virus from the lung within 7 days. Depleting the CD8+ T cells substantially reduced the capacity of these primed mice to deal with the infection, in spite of evidence for established CD4+ T-cell memory. Thus, the control of this relatively mild influenza virus by both primary and secondary CD4+ T-cell responses is relatively inefficient in the absence of B cells and CD8+ T cells.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • B-Lymphocytes / immunology*
  • CD4-Positive T-Lymphocytes / immunology*
  • CD4-Positive T-Lymphocytes / virology*
  • Immunologic Memory
  • Influenza A virus / immunology*
  • Influenza A virus / pathogenicity*
  • Lymphocyte Cooperation
  • Lymphocyte Depletion
  • Mice
  • Mice, Inbred C57BL
  • Orthomyxoviridae Infections / etiology
  • Orthomyxoviridae Infections / immunology