In vivo effect of oral albendazole and albendazole sulphoxide on development of secondary echinococcosis in mice

Int J Parasitol. 1997 Nov;27(11):1341-5. doi: 10.1016/s0020-7519(97)00105-7.

Abstract

This paper describes the effectiveness of ABZ, ABZ.SO and ABZ + ABZ.SO treatment in mice infected with Echinococcus granulosus protoscoleces. The results were evaluated in two ways: measuring the number and wet weight of developed cysts and by transmission electron microscopy (TEM) of tissue cyss. ABZ and ABZ + ABZ.SO had an important effect upon larval growth in E. granulosus. The ultrastructural changes noted were: vacuolation of tegumentary cells of the germinal membrane; increased number of mitochondria; increased number of autophagosomes and an increase in lipid deposits.

Publication types

  • Comparative Study

MeSH terms

  • Administration, Oral
  • Albendazole / analogs & derivatives
  • Albendazole / therapeutic use*
  • Animals
  • Anthelmintics / therapeutic use*
  • Drug Combinations
  • Echinococcosis / pathology
  • Echinococcosis / therapy*
  • Female
  • Mice
  • Mice, Inbred Strains

Substances

  • Anthelmintics
  • Drug Combinations
  • Albendazole
  • albendazole sulfoxide